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KMID : 0043320180410111074
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Archives of Pharmacal Research
2018 Volume.41 No. 11 p.1074 ~ p.1081
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New phenylpropanoids from Bulbophyllum retusiusculum
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Fang Yun-Shan
Yang Ming-Hui
Cai Le
Wang Jia-Peng
Yin Tian-Peng
Yu Jing
Ding Zhong-Tao
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Abstract
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Two new phenylpropanoids, retusiusines A (1) and B (2), and a pair of new phenylpropyl enantiomers, (±)-retusiusine C (3a and 3b), together with eight known compounds, dihydroconiferyl dihydro-p-coumarate (4), methyl 3-(4-hydroxyphenyl) propionate (5), 3-(4-hydroxyphenyl)-propanoic acid (6), dihydroferulic acid (7), methyl 3-(4-methoxyphenyl) propionate (8), 3-(3,4-dimethoxyphenyl)-2-propenal (9), trans-p-coumaric acid (10) and dihydroconiferyl alcohol (11), were isolated from the tubers of Bulbophyllum retusiusculum. The absolute configurations of the new compounds were determined by calculating their electronic circular dichroism (ECD), spectra and specific optical rotations and comparing the calculated values with the experimental data. Compound 2 exhibited potent antifungal activity against Candida albicans (16 μg/mL). Compound 3 showed moderate antibacterial activity against Bacillus subtilis (64 μg/mL).
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KEYWORD
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Bulbophyllum retusiusculum, Phenylpropanoid, Retusiusine, Absolute configuration, Antifungal activity, Antibacterial activity
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